"David Relman (MD,
PhD) and his team at Stanford University and the VA Medical Center in Palo Alto,
California, recently found the genetic fingerprints of several hundred new
bacterial species in the mouths, stomachs, and intestines of healthy
Infectious-diseases specialist Curtis Donskey MD, of Case Western Reserve University in Cleveland, says: "Unfortunately, far too many physicians are still thinking of antibiotics as benign. We're just now beginning to understand how our normal microflora does such a good job of preventing our colonization by disease-causing microbes. And from an ecological point of view, we're just starting to understand the medical consequences of disturbing that with antibiotics."
Science, June 2006: "The ever present armies of microbes in your digestive tract are so essential to your survival, a new study says, that you might consider yourself a super-organism - human plus microbes equals you. These hordes of "gut bugs" perform digestive duties that the human body alone cannot, according to the first ever comprehensive study of these microbes' genes. The study maps the genes of the estimated 500 or more species that live inside us. About a quarter of these genes appear to belong to unknown species."
"We are discovering parts of ourselves we were not aware of," said microbiologist and study co-author Dr. Jeffrey Gordon of the School of Medicine at Washington University in St. Louis, Missouri. "It's a whole other planet down there." ... "Our bodies carry ten times more microbial cells than human cells, and these microbes collectively contain at least a hundred times the number of genes in the human genome."
"Not only are we never alone," said microbiologist David Relman (MD, PhD) of Stanford University in Palo Alto, California. "Our partners contribute essential functions to our collective."
Prescript-Assist® embodies an array of 30 beneficial microorganisms - of human strains, though arguably of Soil Origin (referencing here: bacteria, yeast, fungi, etc.) in a shelf-stable complex with Leonardite. Leodardite is a carbon-based micronutrient complex of humic and fulvic acids, which (among other properties) acts as a food source for our organisms. Activated by moisture, the microorganisms consume the Leonardite, while initiating binary fission (reproductive proliferation) - to the extent of "fulminating". This unprecedented feature offers the benefit of eliminating the need for product loading doses. All clinical studies have been conducted with treatment doses of two capsules per day. Further, as referenced below to herbal or plant nutrients, the effectiveness of any nutritional supplementation (vitamins, minerals, amino acids, phyto-nutrients, herbs, etc.) will be limited by the nature and extent of the gut's microbiota.
"An herbal, or plant nutrients' benefit may be seriously compromised or rendered non-existent, considering that absent proper intestinal microbiota there is a decreased therapeutic effect of some medicinal herbs and phytoestrogen-rich foods" (1). "The activity of many medicinal herbs depends on bacterial enzymatic metabolism in the colon. Of the many enzymes produced by intestinal flora, bacterial beta-glycosidases probably play the most significant role, as many active herbal constituents are glycosides and are inert until the active aglycone is released via enzymatic hydrolysis" (2). 1. Kilkkinen A, Pietinen P, Klaukka T, et al. Use of oral antimicrobials decreases serum enterolactone concentration. Am J Epidemiology 2002;155:472-477. 2. Pengally A. The Constituents of Medicinal Plants, 2nd ed. Crows Nest, Australia: Allen & Unwin; 2004:43-58.
Functions of digestion, assimilation and elimination are altered by antibiotics, as well as a host of other prescription and non-prescription medications. Lifestyle, stress, food and beverage consumption, along with environmental exposures to various chlorinated hydrocarbons, etc. play a significant role in affecting the gut's microbiota, and therefore its proper function; thus, a person's Quality of Life.
Prescript-Assist® -- unlike other formula -- was specifically developed with these factors, and more, in mind. Among other of its attributes, it has been designed to help detoxify harmful environmental phenols and biphenyl chemical compounds. It embodies properties supportive of being a natural chelator and powerful anti-oxidant; both helping to preclude free-radical damage. It eliminates causative factors of intestinal toxemia, while detoxifying chemicals associated with the incomplete digestion of proteins - indole, skatole and phenol. Its anti-inflammatory properties sooth and calm the gut, while normalizing the resident microbiota; thus bringing relief from intestinal bloating, cramping, constipation and diarrhea. P-A is 'Patent Pending' for numerous treatment applications, to include "Travelers' Diarrhea" as it demonstrates broad efficacy for controlling food and water borne pathogens of bacterial, viral, fungal and parasitic origin. [available is a clinical trial for controlling Canine diarrhea, in a Montana study, and Human diarrhea, in a two remote villages in Ecuador.]
Patient Compliance: One of the most significant and contributing factors to pharmacological treatment failures is due to patient non-compliance in taking the medication. The predominant factor associated with non-compliance is: How the medication is affecting the patients' Quality of Life? Many medications present with a host of negative side-effects or "contraindications". Most of these are related to physical and emotional effects commensurate with damage caused to the gut's beneficial microbiota. A little understood fact is that gut microbiota - through their lifecycle, create enzymes, vitamins, minerals, amino acids and other co-enzyme factors, to name just a few, which directly impact (among others) brain chemistry, the endocrine system - and thus hormone balances, etc. Gut microbiota is also responsible for 50-80%% of the body's immune system function. Imagine what happens to a patient when their mental processes and immune system become compromised by the actions of antibiotics to resident gut microbiota? People are thinking: 'if this drug is supposed to help me, why do I feel so rotten?' Remember what Dr. Donskey had to say about our normal microflora, and antibiotics: "we're just starting to understand the medical consequences of disturbing that with antibiotics".
"Irritable Bowel Syndrome (IBS) affects 25 million Americans, and is the leading cause of work-related absence." [Harvard Women's Health Watch, April 2004.]
"Upward of $30 billion is spent annually on this condition (excluding prescription and over-the-counter medications). Although the direct costs associated with IBS are substantial, the indirect costs from productivity losses in the workplace appear to be even greater." Hulisz D. The burden of illness of irritable bowel syndrome: current challenges and hope for the future. J Managed Care Pharm. 2004;10:299-309.
"Another form of indirect cost that is less recognized is the decrement in quality of life (QOL) wrought by IBS; it is well established that IBS patients experience decreased QOL." Frank L, Kleinman L, Rentz A, Ciesla G, Kim JJ, Zacker C. Health-related quality of life associated with irritable bowel syndrome: comparison with other chronic diseases. * Clinical Therapeutics. 2002;24:675-689.
Prescript-Assist® -- throughout its five years of Clinical Development, Test and Evaluation (CDTE) has distributed remarkable efficacy toward alleviating IBS - usually in 4 ~ 6 weeks; absent the imposition of any dietary restrictions. Please review the associated manuscript; published to *Clinical Therapeutics 2005; 27:755-761, with the attending "draft abstract" for completion of the second portion to the study. This is due to be submitted to Clinical Therapeutics' editorial review board, later this summer.
Prescript-Assist® could certainly represent a premium product of Optimum Nutrition, paving the way for better assimilation of nutritional supplementation, helping to assure a greater sense of wellbeing -- especially where your customers may already have issues concerning past or present medication use. By offering easy to read literature (or even a CD) detailing the critical importance of our gut microbiota, and how they are disrupted by our lifestyle, medications, etc., would speak volumes as to Optimum Nutrition's visionary principle of - "Client Education, the Foundation of Sustained Relationships"
I would ask: What is it that currently defines Optimum Nutrition today?
I would propose: Providing "Quality of Life" product technologies, supported by scientific research and evidence-based medicine.
Simply Stated: Prescript-Assist® - It's a Gut Feeling!
WebMD http://www.webmd.com/content/article/114/111304 June 19, 2006
By Daniel DeNoon, WebMD Medical News
Reviewed By Brunilda Nazario, MD on Monday, October 31, 2005
Oct. 31, 2005 - It's not a Halloween prank. Live bugs are the hottest new treatment for irritable bowel syndrome (IBS).
The "bugs" aren't insects. They're live bacteria. When bad bacteria grow in our bodies, we call them germs. Good bacteria ingested for health effects are called probiotics.
Probiotics already are in your grocery and health food store in capsules, tablets, gel caps, liquids, and in cultured yogurt products. Not every probiotic product has proven health effects. But as a medical treatment, they're more than just the latest health fad, says University of New Mexico researcher Mohamed O. Othman, MD. [Emphasis added]
Othman is one of several researchers reporting on probiotics research at this week's 70th annual scientific meeting of the American College of Gastroenterology in Honolulu. "Probiotics now have been used in many diseases, not only IBS but also ulcerative colitis and Crohn's disease and in both children and adults with lactose intolerance," Othman tells WebMD. "It is a new field, and there is a lot of investigation going on."